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Antihistamines that target the histamine H receptors in the upper gastrointestinal tract, primarily in the stomach.

Histamine receptors exhibit constitutive activity, so antihistamines can function as either a neutral receptor antagonist or an inverse agonist at histamine receptor.

Antihistamines for Hives (Urticaria)Oral antihistamines are the main treatment for hives.

Core CMIfor Antihistamines (text in italics is instructional for the CMI writer only) 30 November2005 [Medicine name] 1 [Medicine name]  (Ifyouwantto include phonetic spelling, the Second Edition of the Usability Guidelines suggests using the system outlined in the Webster's International ...Certain H1 antagonists, such as promethazine, have a local anesthetic effect.Other H1-antihistamines having an important antimuscarinic activity like diphenhydramine and dimenhydrinate, are used in preventive and curative treatment of motion sickness, but scopolamine which has no antihistamine effect seems more effective than them in preventive treatment.Older antihistamines, such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), and hydroxyzine (Atarax), also work well but have many side effects.Oral antihistamines work well when taken as-needed, meaning that allergy symptoms improve within an hour or two of taking the medication.

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